GC method development steps may include:

Initial column selection (capillary/mega, phase, length,
         diameter[s] based on known analytes)
Carrier Gas selection
Carrier Gas average linear velocity optimization
Detection mode selection
Injection mode selection (direct, split, splitless,
         headspace, purge and trap, injection volume)
Injection volume optimization
Initial oven temperature selection
Initial oven temperature ramp selection
Oven temperature ramp optimization
Final temperature and program optimization
Hold time
Detector temperature
Headspace conditions optimization (Split flow ratio, etc)
Purge and trap conditions optimization, if needed
Column head pressure
GC Method Development
Let us assist you
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WPBAD, 5093 El Claro E, West Palm Beach, Fl 33415      method.development@gmail.com      wpbad.biz
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Detection Mode expertise:


GC System expertise:

Perkin Elmer

We use systematic GC method development strategies to create rapid, reproducible, robust, transferable, and most importantly approved methods.  Comprehensive method development reports are written, reviewed, applicable changes made, and totally QA reviewed in preparation for submission, if applicable.  The actual development will be performed at your site.
GC Solvent Expertise:

Solvents to Avoid: (Benzene, Carbon tetrachloride, 1,2-Dichloroethane, 1,1-Dichloroethene, 1,1,1-Trichloroethane);
Solvents to Be Limited: (Acetonitrile, Chlorobenzene, Chloroform, Cyclohexane, 1,2-Dichloroethene, Dichloromethane, 1,2-Dimethoxyethane, N,N-Dimethylacetamide, N,N-Dimethylformamide, 1,4-Dioxane, 2-Ethoxyethanol, Ethylene glycol, Formamide, Hexane, Methanol, 2-Methoxyethanol, Methylbutylketone, Methylcyclohexane, N-Methylpyrrolidone, Nitromethane, Pyridine, Sulfolane, Tetralin, Toluene, 1,1,2-Trichloroethene, Xylene);
Solvents with Low Toxic Potential: (Acetic acid, Acetone, Anisole, 1-Butanol, 2-Butanol, Butyl acetate, tert-Butylmethyl ether, Cumene, Dimethylsulfoxide, Ethanol, Ethyl acetate, Ethyl ether, Ethyl formate, Formic acid, Heptane, Isobutyl acetate, Isopropyl acetate, Methyl acetate, 3-Methyl-1-butanol, Methylethyl ketone, Methylisobutyl ketone, 2-Methyl-1-propanol, Pentane, 1-Pentanol, 1-Propanol, 2-Propanol, Propyl acetate, Tetrahydrofuran);
Solvents for which No Adequate Toxicological Data was Found: (1,1-Diethoxypropane, 1,1-Dimethoxymethane, 2,2-Dimethoxypropane, Isooctane, Isopropyl ether, Methylisopropyl ketone, Methyltetrahydrofuran, Petroleum ether, Trichloroacetic acid, Trifluoroacetic acid)

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